Signal Intensity Changes in the Dentate Nucleus and Globus Pallidus of Multiple Sclerosis Patients Undergoing Multiple Brain Magnetic Resonance Imaging with Gadolinium-Based Contrast Agents

Objective: To investigate the correlation between cumulative doses of gadolinium-based contrast agents and increased signal intensity (SI) in dentate nucleus (DN) globus pallidus (GP). Methods: Our retrospective trial involved 21 multiple sclerosis patients (11 women, 10 men; mean age: 39.21±10.24, range: 20 to 57 years) who underwent a serial number cranial magnetic resonance imaging (MRI) examinations radiology department our tertiary care center. Average intensities on DN, pons, GP thalamus unenhanced T1-weighted images were taken into account. The DN was proportioned whereas thalamus. Any relationship DN-to-pons or GP-to-thalamus ratios previous administrations sought by means repeated measures ANOVA. Results: Increases both displayed significant with (p<0.001 for both). A remarkable increase detected first last MRI Conclusion: results support association SI gadolinium-enhanced scans MS patients. T1 seems be linked enhanced scans.